Smads and early developmental signaling by the TGFbeta superfamily

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Smads and early developmental signaling by the TGFbeta superfamily.

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TGFbeta signaling controls diverse normal developmental processes and pathogenesis of diseases including cancer and autoimmune and fibrotic diseases. TGFbeta responses are generally mediated through transcriptional functions of Smads. A key step in TGFbeta signaling is ligand-induced phosphorylation of receptor-activated Smads (R-Smads) catalyzed by the TGFbeta type I receptor kinase. However, ...

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ژورنال

عنوان ژورنال: Genes & Development

سال: 1998

ISSN: 0890-9369

DOI: 10.1101/gad.12.16.2445